B3/A3 rearrangement in a patient with chronic myeloid leukemia [1]

Abstract:

The role of BCR/ABL isoforms and their relationships to leukemia phenotype are discussed continuously because of the variety of information reported. Here we describe a man with CML an atypical b3/a3 rearrangement, who had a good response to INFα treatment. This may be due to a deletion of the ABL exon 2 sequences, which are an essential part of the ABL SH3 domain inducing STAT5 expression, which is indeed crucial for the BCR/ABL leukemogenesis; because of its role in anti-apoptotic activity and cell cycle progress.

Año de publicación:

2003

Keywords:

• INFα
• B3/A3
• CML
• BCR/ABL

Fuente:

scopus

google