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BCR-ABL rearrangement frequencies in chronic myeloid leukemia and acute lymphoblastic leukemia in Ecuador, South America

Abstract:

Different BCR-ABL transcript variants occur more or less frequently, according to the leukemia type. We report the frequencies of BCR-ABL transcript variants studied in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) patients in the Ecuadorian population. The frequencies found for CML patients in this study were 94.6% for the b2/a2 rearrangement and 5.4% for the b3/a2 rearrangement; whereas in ALL, all cases (100%) that presented the BCR-ABL rearrangement had the e1/a2 junction. Since our results differ from the frequencies previously reported, we suggest that this may be due to a different genetic background in the population involved in this study when compared to the populations analyzed in prior studies. Furthermore, we recommend a survey of the BCR-ABL transcript variants and their frequencies in different ethnic groups. © 2002 Elsevier Science Inc. All rights reserved.

Año de publicación:

2002

Keywords:

    Fuente:

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    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

      Áreas temáticas:

      • Enfermedades

      Contribuidores:

      Fiallo B.F.Fiallo B.F.
      Morillo S.A.Morillo S.A.
      Cesar Paz-y-MiñoCesar Paz-y-Miño
      Paola E. LeonePaola E. Leone
      Burgos R.I.Burgos R.I.
      Santos J.C.Santos J.C.
      Paz-Y-Mio C.Paz-Y-Mio C.