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Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

Abstract:

We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii and established that the bacterial capsule is the receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible for capsule biosynthesis, resulting in capsule loss and disruption of phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam antibiotics and alternative phages and exhibited diminished fitness in vivo. Using a mouse model of A. baumannii infection, we showed that phage therapy was effective.

Año de publicación:

2021

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Microbiología
    • Microbiología

    Áreas temáticas:

    • Microorganismos, hongos y algas
    • Enfermedades

    Contribuidores:

    Forsyth J.H.Forsyth J.H.
    Barr J.J.Barr J.J.
    Trim M.Trim M.
    Lithgow T.J.Lithgow T.J.
    Fernando Gordillo AltamiranoFernando Gordillo Altamirano
    O’Bryan M.K.O’Bryan M.K.
    Subedi D.Subedi D.
    Kielty L.Kielty L.
    Peleg A.Y.Peleg A.Y.
    Oliveira C.Oliveira C.
    Archer S.K.Archer S.K.
    Kostoulias X.Kostoulias X.
    Patwa R.Patwa R.
    Korneev D.Korneev D.
    Morris F.C.Morris F.C.