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A novel approach to childhood obesity: circulating chemokines and growth factors as biomarkers of insulin resistance

Abstract:

Background Insulin resistance (IR) in children with obesity constitutes a risk factor that should be precisely diagnosed to prevent further comorbidities. Objective Chemokines were evaluated to identify novel predictors of IR with clinical application. Methods We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain‐derived neurotrophic factor, pro‐fibrotic platelet‐derived growth factor [PDGF‐BB] and insulin‐like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non‐IR) and 32 controls. Factor analysis, correlation, binary logistic regression and receiver operating characteristic analysis of combined biomarkers were used to validate their capability for preventive interventions of IR …