A novel approach to childhood obesity: circulating chemokines and growth factors as biomarkers of insulin resistance

Abstract:

Background Insulin resistance (IR) in children with obesity constitutes a risk factor that should be precisely diagnosed to prevent further comorbidities. Objective Chemokines were evaluated to identify novel pbkp_redictors of IR with clinical application. Methods We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain‐derived neurotrophic factor, pro‐fibrotic platelet‐derived growth factor [PDGF‐BB] and insulin‐like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non‐IR) and 32 controls. Factor analysis, correlation, binary logistic regression and receiver operating characteristic analysis of combined biomarkers were used to validate their capability for preventive interventions of IR …

Año de publicación:

2019

Keywords:

Fuente:

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