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A novel heterobimetallic Ru(ii)-Gd(iii) complex-based magnetoluminescent agent for MR and luminescence imaging

Abstract:

A novel heterobimetallic ruthenium(ii)-gadolinium(iii) complex, Ru-Gd, comprising a luminescent Ru(ii) complex, [Ru(bpy)2(phen)]2+ (bpy: 2,2′-bipyridine; phen: 1,10-phenanthroline), and a Gd(iii) complex, DOTA-Gd3+ (DOTA: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), has been designed and synthesized as a magnetoluminescent dual-modal imaging agent. The heterobimetallic complex Ru-Gd is water-soluble, biocompatible with low cytotoxicity, strongly luminescent with a long luminescence lifetime and a large Stokes shift, and has comparable longitudinal relaxivity r1 (4.71 mM-1 s-1), which enable the complex to be suitable for luminescence bioimaging and T1-weighted MR imaging. Using Ru-Gd as a contrast agent, the T1-weighted MRI of a Kunming (KM) mouse was successfully carried out. The results demonstrated the availability and validity of our approach for the development of magnetoluminescent dual-modal imaging agents.