Regresar

Bio-informatic model of tyrosine kinases inhibitors in trabecular meshwork cells

Abstract:

The behavior of potassium ion (K+) establishes the repolarization and hyperpolarization states in the cell membrane of trabecular meshwork cells. One of the main proteins that controls this ion is calcium-dependent potassium maxi-channels BKca, their malfunction evoked by tyrosine kinases, destabilize the control of aqueous humor flow and the increase of intraocular pressure, responsible of glaucoma. In the present work, the ionic behavior of ion K+ of trabecular cells is detailed, when genistein and tyrphostin-51 are applied in culture cells. The flow behavior is described by means of mathematical expressions based on exponential functions and equations of line. Genistein and tyrphostin-51 drugs are compared in their efficiency of inhibiting tyrosine kinases from the mathematical functions provided by the proposed method. The present study describes the ion behavior regarding K+ potassium which is controlled by maxi-channels BKca that come from trabecular meshwork when genistein and tyrphostin-51 are applied in culture cells. The behavior of this flow is described by mathematical expressions. Thus, inhibitor drugs effect and characteristic time behavior are compared using their mathematical function.