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A novel series of potent γ-secretase inhibitors based on a benzobicyclo [4.2. 1] nonane core

Abstract:

A new series of γ-secretase inhibitors was developed from an in-house screening hit based on a benzobicyclo[4.2.1]nonane core. Lead optimisation studies led to the development of a series of potent inhibitors and in vivo efficacy was demonstrated.

Año de publicación:

2005

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Descubrimiento de fármacos
    • Bioquímica

    Áreas temáticas:

    • Química orgánica
    • Farmacología y terapéutica

    Contribuidores:

    Harrison CastroHarrison Castro