Biomonitoring in children exposure to heavy metals

Abstract:

The biomonitoring evaluate the health status of exposed populations to mutagens or carcinogens trough biomarkers of exposure, effect and susceptibility. The constant exposure to heavy metals independently of their anthropological or environmental origin represent a potential risk for children, existing a larger tendency in order to develop genetic, dermises, neurological and digestive pathologies, during pregnancy or childhood. Diverse studies in vitro and in vivo demonstrate that heavy metals can generate permanent modifications in the genetic material, resultant of the oxidative damage at cellular level induced by reactive kinds of oxygen, which play an important role in the development of human cancers, this toxicity liberates noxious action mechanisms at cell level which produces cytogenetic alterations, fractures to the ADN, mutations, alterations in the reparation or replication processes, which can drive to genomic instability, changes on the progression of cell cycle or apoptosis. The cytogenetic markers in monitoring studies in human populations exposed to genotoxic substances: chromosome aberrations, of chromatid sisters interchanges, micronuclei and comet assay are utilize to identify the standing level of individuals and populations risk. In Ecuador the presence of arsenic and heavy metals of natural origin has been found in the provinces of Carchi, Imbabura, Pichincha, Cotopaxi and Tungurahua at dregs, geothermal, subterranean and superficial waters. The project outlines the monitory of exposed children to heavy metals, with the objective of determine the damage in the DNA, through the applications of exposure markers …

Año de publicación:

2010

Keywords:

Fuente:

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