Black adrenal adenoma causing Cushing’s syndrome: 40 years ago and today

Abstract:

Black adrenal adenomas are adrenal cortical tumors that are black or dark brown on cut sections. The first case of black adrenal adenoma was reported in 1938. 1 Autopsy studies published in the early 1970s suggest that the pigments in black adrenal adenomas are made of lipofuscin, a lysosomal material, and that these tumors are common autopsy findings (10% on random adrenal sections and 37% on fine sections) but do not secrete hormones. 2 In 1973, two of us (GDB and RRE) cared for and studied a patient with a black adrenal adenoma that caused ACTH-independent Cushing’s syndrome. We here describe the case and discuss it in historical background and in light of the literature on this topic in the last 40 years. A 42-year-old Caucasian female had been well until 1966 when she developed hypertension, edema, and hyperglycemia during her third pregnancy. In 1969, she developed

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