Block-co-polymer nanostructures for DNA biosensing

Abstract:

The development of labeless and/or reagent-less detection approaches remains a very active research topic in the field of optical and electrochemical biosensors. The perspective of rapid analysis requiring very few sample handling and processing steps coupled to rapid detection would allow cheaper diagnostics and faster sample-to-results turnaround. The use of nanostructured films in biosensing is a versatile tool to develop and satisfy the size requirement for many lab-on-a-chip technologies. To achieve this goal, block copolymer films containing cylindrical gaps were prepared on gold substrates by removing the poly(methyl methacrylate)(PMMA) domains from poly(styrene-b-methyl methacrylate) (PS-b-PMMA) spin coated films via UV degradation and chemical etching with acetic acid, using different approaches to orient nanodomains (thermal and solvent annealing and electric fields). Spin coating conditions …

Año de publicación:

2010

Keywords:

Fuente:

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