A powerful non-homology method for the pbkp_rediction of operons in prokaryotes

Abstract:

Motivation: The pbkp_rediction of the transcription unit organization of genomes is an important clue in the inference of functional relationships of genes, the interpretation and evaluation of transcriptome experiments, and the overall inference of the regulatory networks governing the expression of genes in response to the environment. Though several methods have been devised to pbkp_redict operons, most need a high characterization of the genome analysed. Log-likelihoods derived from inter-genic distance distributions work surprisingly well to pbkp_redict operons in Escherichia coli and are available for any genome as soon as the gene sets are pbkp_redicted. Results: Here we provide evidence that the very same method is applicable to any prokaryotic genome. First, the method has the same efficiency when evaluated using a collection of experimentally known operons of Bacillus subtilis. Second, operons …

Año de publicación:

2002

Keywords:

Fuente:

google