CCK-4 restricted analogues containing a 3-oxoindolizidine skeleton

Abstract:

A series of CCK-4 restricted analogues, incorporating a 3-oxoindolizidine bicyclic lactam as conformational constraint, is described. The 8-(Boc-tryptophyl)amino-2-benzyl derivatives behave as weak CCK-A or CCK-B receptor antagonists. The main factors for selectivity are the configuration at C-2 position of the 3-oxoindolizidine ring and at the Trp residue.

Año de publicación:

1996

Keywords:

Fuente:

scopus

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