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CD2 is involved in regulating cyclic AMP levels in T cells

Abstract:

The human T lymphocyte‐specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP comparable to that induced by reagents which activate adenylate cyclase. These results indicate that there is a relationship between the CD2 membrane molecule and the adenylate cyclase system. Copyright © 1988 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

Año de publicación:

1988

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Inmunología
    • Inmunología

    Áreas temáticas:

    • Fisiología humana
    • Fisiología y materias afines
    • Enfermedades

    Contribuidores:

    Carrera A.C.Carrera A.C.
    Manuel Ortiz de LandázuriManuel Ortiz de Landázuri
    López‐Botet M.López‐Botet M.
    Rincon M.Rincon M.