A randomized prospective study on the treatment of nontuberculous mycobacterial head and neck infections in children: preliminary results of surgery versus medical therapy

Abstract:

Materials and Methods: Sixty-five children between the ages of 1 and 12 years with a persistent cervicofacial lymph node swelling were subjected to a diagnostic protocol. Inclusion criteria for the study were 1) a cervicofacial lymph node swelling; 2) a positive mycobacterial skin test, or positive stain, positive culture for mycobacteria or positive PCR for mycobacteria; and 3) a negative PCR for Mycobacterium tuberculosis. Exclusion criteria were immunocompromised patients, use of immunosuppressive drugs, patients older than 15 years, and refusal to participate in the study of the patient, parent, or legal representative. Forty children were included and were randomized to either surgical excision of the affected lymph nodes or medical therapy consisting of claritromycin and rifabutin during 3 months. Primary outcome was complete closure of the wound or resolution of the lymphadenitis after 6 months with medical …

Año de publicación:

2003

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Fuente:

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