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CRISPR-Cas Activators for Engineering Gene Expression in Higher Eukaryotes

Abstract:

CRISPR-Cas-based transcriptional activators allow genetic engineers to specifically induce expression of one or many target genes in trans. Here we review the many design variations of these versatile tools and compare their effectiveness in different eukaryotic systems. Lastly, we highlight several applications of programmable transcriptional activation to interrogate and engineer complex biological processes.

Año de publicación:

2020

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Review

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Biología molecular

    Áreas temáticas:

    • Bioquímica
    • Genética y evolución
    • Anatomía humana, citología, histología

    Contribuidores:

    Smanski M.J.Smanski M.J.
    Zinselmeier M.H.Zinselmeier M.H.
    Juan Armando Casas-MollanoJuan Armando Casas-Mollano
    Erickson S.E.Erickson S.E.