A retrospective, cohort-based survey of patients using twice-daily indinavir+ ritonavir combinations: pharmacokinetics, safety, and efficacy

Abstract:

Objective: To describe the pharmacokinetics, safety, and efficacy of twice-daily indinavir+ ritonavir regimens Design: A cohort-based survey of HIV-infected patients who either used indinavir 800 mg+ ritonavir 100 mg twice daily or indinavir 400 mg+ ritonavir 400 mg twice daily. Methods: Data were extracted from a database of samples sent to our laboratory for measurement of indinavir+ ritonavir plasma concentrations. Patient characteristics, safety, and efficacy measurements were collected by retrospective chart review. Results: 100 Patients using 800-mg indinavir+ 100-mg ritonavir twice daily and 32 patients using 400-mg indinavir+ 400-mg ritonavir twice daily were eligible. Median peak and trough concentrations of indinavir were 6.8 and 0.77 mg/L in the 800/100 group and 2.6 and 0.45 mg/L in the 400/400 group. The most frequently found side effects were nausea and vomiting, which occurred in 22.1% and 34.9 …

Año de publicación:

2001

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