Caracterización de dos proteínas efectoras putativas de Citrobacter rodentium NleN y NleO

Abstract:

Citrobacter rodentium is a Gram-negative, mouse-restricted pathogen, commonly used as a murine infection model for clinically important human pathogenic strains of Escherichia coli, such as enterohaemorrhagic E. coli (EHEC) and enteropathogenic E. coli (EPEC). These pathogens primary infection strategy is the intimate attachment to the host’s gut epithelial cells, in order to translocate toxins, termed effectors. Intimate attachment is achieved through the formation of A/E (Attaching/Effacing) lesions, which depends on the Type 3 Secretion System (T3SS). The T3SS is the ‘injectosome’through which effectors are translocated. Effectors target host cellular processes and signalling pathways in order to subvert immune responses, alter the cell cycle and allow bacterial proliferation. Despite the fact that many effectors have been characterised, the number of signalling pathways targeted and infection strategies …

Año de publicación:

2016

Keywords:

Fuente:

google