A simple and efficient preparation of 3,4-dialkylsubstituted tetrahydroisoquinoline using cyclopropylethyliden benzylamine

Abstract:

Intramolecular Friedel-Crafts alkylation of N-benzyl-N-(1-cyclopropylethyl)acetamide to 3,4-dialkyl substituted tetrahydroisoquinoline by reaction of the acetamide with an excess of PPA is described. The conformational study of intermediates by high resolution NMR analysis is also reported.

Año de publicación:

2002

Keywords:

Fuente:

scopus