Characterization Of Sox10 Transcription Factor In The Goldfish Visual System In Control And Regeneration

Abstract:

Purpose:: The Sox10 transcription factor belongs to the SoxE subfamily and participates in the oligodendrocyte lineage formation, differentiation and survival during development in vertebrates. Sox10, in particular, is necessary in oligodendrocyte differentiation and controls the expression of some myelin genes such as MBP. Moreover, it seems that it promotes the gene expression of factors that mediate the oligodendrocyte-axon interactions, necessary for oligodendrocyte survival. In adults, mature oligodendrocytes maintain sox10 expression keeping their glial phenotype. Here we have characterized a Sox10+ population in the goldfish retina and optic nerve, a model of continuous growth and regeneration. Methods:: We used goldfish as controls and others injured with a cryo-lesion of the peripheral retina (CL) and an optic nerve crush (OC). They were maintained from 2 to 210 days post-injury, in accordance with …

Año de publicación:

2012

Keywords:

Fuente:

google