Chemical composition and anticholinesterase activity of the essential oil from the Ecuadorian plant Salvia pichinchensis Benth

Abstract:

Salvia pichinchensis Benth was collected in the South of Ecuador and the essential oil (EO) was distilled from aerial parts and analyzed by GC-MS and GC-FID. The physical properties, chemical composition, and cholinesterase inhibitory activity were determined. Six major components, all sesquiterpenes, were identified: cis-cadina-1 (6), 4-diene (17.11%)(1), γ-curcumene (13.75%)(2),(E)-caryophyllene (12.58%)(3),(E, E)-α-farnesene (10.00%)(4), α-gurjunene (9.46%)(5) and allo-aromadendrene (6.96%)(6). The EO showed an interesting selective inhibitory activity against the enzyme butyrylcholinesterase (50.70 μg/mL) and only low inhibitory activity against acetylcholinesterase (117.60 μg/mL). The chemical composition and butyrylcholinesterase activity of the EO of S. pichinchensis Benth was reported for first time.

Año de publicación:

2020

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