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Chemical profiling of cerebrospinal fluid by multiple reaction monitoring mass spectrometry

Abstract:

We report an accelerated biomarker discovery workflow and results of sample screening by mass spectrometry based on multiple reaction monitoring (MRM). This methodology shows promising initial results for the currently unsolved challenge of Parkinson's disease (PD) laboratory diagnosis by biomarker screening. Small molecules present in cerebrospinal fluid (CSF) at low parts per million levels are monitored using specific transitions connecting ion pairs. A set of such transitions constitutes a multidimensional chemical profile used to distinguish and characterize different CSF samples using multivariate statistical methods.

Año de publicación:

2016

Keywords:

    Fuente:

    scopusscopus
    googlegoogle

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Espectrometría de masas

    Áreas temáticas:

    • Química analítica

    Contribuidores:

    Fernanda Bertuccez CordeiroFernanda Bertuccez Cordeiro
    Espy R.D.Espy R.D.
    Ouyang Z.Ouyang Z.
    Mollenhauer B.Mollenhauer B.
    Cooks R.G.Cooks R.G.
    Ferreira C.R.Ferreira C.R.
    Yannell K.E.Yannell K.E.