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Chemistry and biological activity of polyisoprenylated benzophenone derivatives

Abstract:

Plants of the family Clusiaceae or Guttiferae, in articular those belonging to the genera Clusia, and Garcinia, produce a series of oxidized and polyisoprenylated benzophenone derivatives, some of which are structurally complex and biologically active. From a biogenetic point of view, these compounds may be considered as benzophenones in which the acetate derived benzene ring is modified by intervention of isoprenyl groups. Several compound belonging to this class have shown a wide range of biological activity such as antimicrobial, antifungal, anticarcinogenic and anti-HIV inhibitory activities. In this chapter we shall review the chemistry and biological activity of the polyisoprenylated benzophenone derivatives isolated from the genera Clusia, Garcinia, Vismia, Allanblackia, Moronobea, Symphonia, Hypericum, Tovomita, Tovomiptosis and Ochrocarpus. © 2005 Elsevier B.V. All rights reserved.