Chemokines in Trypanosoma cruzi infection.

Abstract:

The inflammatory response triggered by Trypanosoma cruzi infection is necessary for host resistance and also contributes to the disparate pathology seen in Chagas' disease. Here, we discuss a new role for chemokines in signalling human macrophages through their chemokine receptors to display an effector function, which is the induction of microbicidal activity of these cells via a NO-dependent mechanism. We also examine the signal transduction events induced by chemokines in human macrophages and their impact on the modulation of macrophage surface molecules important in inflammatory reactions. Finally, we examine the mechanisms underlying chemokine production following infection in vitro and in vivo (in mice and humans), and the capacity of chemokines to modulate the influx of inflammatory and immune cells to sites of parasite infection for parasite clearance.

Año de publicación:

2003

Keywords:

Fuente:

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