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Chemoselective Disulfide Formation by Thiol-Disulfide Interchange in SIT-Protected Cysteinyl Peptides

Abstract:

Chemoselective disulfide formation is accomplished through a thiol-disulfide interchange approach using sec-isoamyl mercaptan (SIT) as an alkyl sulfenyl-protecting group of one of the Cys residues involved in the pairing. SIT has a dual and unique characteristic, acting as a masking group during the synthesis and directing disulfide formation in the presence of a free thiol. This novel approach is illustrated by the synthesis of several peptides of biological interest.

Año de publicación:

2022

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Péptido
    • Bioquímica

    Áreas temáticas:

    • Química orgánica
    • Química inorgánica
    • Química física

    Contribuidores:

    Chakraborty A.Chakraborty A.
    Alberício F.Alberício F.
    B. G. De la TorreB. G. De la Torre