Chemotactic Activity of CXC Chemokines Interleukin-8, Growth-Related Oncogene—α, and Epithelial Cell—Derived Neutrophil-Activating Protein—78 in Urine of …

Abstract:

CXC chemokines are chemotactic cytokines that specifically act on neutrophils. To obtain insight into the extent of local production of CXC chemokines during acute pyelonephritis, interleukin (IL)—8, growth-related oncogene (GRO)—α, and epithelial cell—derived neutrophilactivating protein (ENA)—78 were measured in urine and plasma samples from patients with culture-proven urosepsis (n = 33), healthy human control subjects with sterile urine (n = 31), and human volunteers intravenously injected with endotoxin (n = 11). Patients had profoundly elevated urine concentrations of chemokines with no (GRO-α and ENA-78) or little (IL-8) elevation in plasma. Endotoxin-challenged subjects demonstrated transient increases in plasma chemokine concentrations, with no (GRO-α) or little (IL-8 and ENA-78) elevation in urine. Urine from patients exerted chemotactic activity toward neutrophils, which was partially …

Año de publicación:

2000

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Fuente:

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