Chimpanzee CD4+ T cells are relatively insensitive to HIV‐1 envelope‐mediated inhibition of CD154 up‐regulation

Abstract:

CD40‐CD154 interaction forms a key event in regulation of crosstalk between dendritic cells and CD4 T cells. In human immunodeficiency virus (HIV)‐1 infected patients CD154 expression is impaired, and the resulting loss of immune responsiveness by CD4+ T cells contributes to a progressive state of immunodeficiency in humans. Although chimpanzees are susceptible to chronic HIV‐1/SIVcpz infection, they are relatively resistant to the onset of AIDS. This relative resistance is characterized by maintenance of CD4+ T cell populations and function, which is highly compromised in human patients. In our cohort of chronically HIV‐1‐ and SIVcpz‐infected chimpanzees, we demonstrated the capacity to produce IL‐2, following CD3/CD28 stimulation, as well as preserved CD154 up‐regulation. Cross‐linking of CD4 with mAb was found to inhibit CD3/CD28‐induced up‐regulation of CD154 equally in chimpanzees …

Año de publicación:

2008

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Fuente:

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