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Chronotherapy of breast cancer induced by N-nitrosomethylurea in the rat. I. Effect of a high dose of cyclophosphamide administered at 8:00 and 14:00 hours

Abstract:

The administration of cyclophosphamide (200 mg/kg) intraperitoneally produces a high mortality in Wistar rats bearing mammary tumors induced by N-methylnitrosourea. The effect is more marked when the drug is administered at 8:00 A.M. than when given at 2:00 P.M. The injection of cyclophosphamide at 2:00 P.M. slowers the tumor growth, the effect being significative after two weeks compared with the control animals, and after four weeks when compared with the animals receiving the drug at 8:00 A.M.

Año de publicación:

1984

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Cáncer
    • Cáncer

    Áreas temáticas:

    • Farmacología y terapéutica
    • Enfermedades
    • Temas específicos de historia natural de los animales

    Contribuidores:

    Urcia M.A.Urcia M.A.
    Lafarga L.Lafarga L.
    Leal M.C.Leal M.C.
    Faustino R. Pérez-LópezFaustino R. Pérez-López
    Hergueta J.Hergueta J.
    Torralba R.Torralba R.
    Guillén V.Guillén V.