Circulating mtDNA levels as an early marker for metabolic syndrome

Abstract:

Chronic diseases, infection and physical activity are conditions related with metabolic or oxidative stress and the releasing of mitochondria to circulation by cells. This might be due to apoptosis or transference of mitochondria from one cell to another, either as survival or as tissue repair process. Circulating levels of cell-free mitochondrial DNA (ccf-mtDNA), although controversial, have been used for cancer and sepsis diagnose. The objective of this study was to investigate the relationship between ccf-mtDNA and metabolic syndrome. In this sense, after IRB approval, healthy subjects (n=32) and adults with diabetes (n=6) were invited to participate. Body mass index (BMI) was calculated and fasting glucose measured as biomarker of metabolic syndrome. In addition, DNA was extracted from serum and real time PCR used to detect ccf-mtDNA and both parameters were compared. Our data showed that ccf-mtDNA …

Año de publicación:

2017

Keywords:

Fuente:

google