A-18 Early Pattern of Cognitive Changes Associated with Insulin Resistance in a Sample of Young Adults

Abstract:

Objective Insulin resistance increases the risk of developing type 2 diabetes and subsequently cardiovascular and cerebrovascular disease. It is also linked to neurocognitive disorders and accelerated cognitive aging (Ekblad et al, 2017; Levine, Harrati, & Crimmins, 2018). Using baseline data from a longitudinal study in a sample of 126 cognitively intact adults aged 25–50 years (36.5% males), we assessed cognitive performance in relation to insulin resistance to determine whether an early prodromal pattern of cognitive changes exists prior to advanced metabolic disease. Methods Steady state plasma glucose (SSPG) was used to measure insulin resistance. Multivariate regression analyses were conducted using age, years of education, body mass index (BMI), and SSPG as pbkp_redictors of neuropsychological functioning. In-person and tele-neuropsychological assessment was administered using standard …

Año de publicación:

2021

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Fuente:

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