A-28 Vascular Risk and Cognitive Decline in Older Adults with and without Mild Cognitive Impairment (MCI).

Abstract:

Objective: Vascular risk factors are associated with increased risk for cognitive decline and clinical Alzheimer's disease (AD). The purpose of this study was to examine whether worse vascular health status would be associated with a decline in cognitive performance in older adults with normal cognition (NC) or mild cognitive impairment (MCI) at baseline. Method: Participants were drawn from the National Alzheimer's Coordinating Center Uniform Dataset, and included 5893 NC (72±8 years, 69% female) and 2769 MCI (74±8 years, 55% female). Vascular Health was defined using the Framingham Stroke Risk Profile score (based on age, systolic blood pressure, anti-hypertensive medication usage, diabetes, cigarette smoking, CVD history, atrial fibrillation). Cognitive performance was assessed using a comprehensive neuropsychological protocol (Mini-Mental State Examination, Digit Span, Trail Making Test Parts …

Año de publicación:

2014

Keywords:

Fuente:

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