Regresar

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update

Abstract:

Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the variant allele HLA-B*15:02 is associated with an increased risk of Stevens–Johnson syndrome and toxic epidermal necrolysis in response to phenytoin treatment. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for the use of phenytoin based on CYP2C9 and/or HLA-B genotypes (updates on cpicpgx.org).

Año de publicación:

2021

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Review

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Farmacología

    Áreas temáticas:

    • Farmacología y terapéutica
    • Medicina y salud
    • Enfermedades

    Contribuidores:

    Ta Michael Lee M.Ta Michael Lee M.
    Karnes J.H.Karnes J.H.
    Fohner A.E.Fohner A.E.
    Gaedigk A.Gaedigk A.
    Rettie A.E.Rettie A.E.
    Phillips E.J.Phillips E.J.
    Adrián LLerenaAdrián LLerena
    Callaghan J.T.Callaghan J.T.
    Klein T.E.Klein T.E.
    Caudle K.E.Caudle K.E.
    Whirl-Carrillo M.Whirl-Carrillo M.
    Formea C.M.Formea C.M.
    Huddart R.Huddart R.
    Mintzer S.Mintzer S.
    Somogyi A.A.Somogyi A.A.