Clinical pbkp_redictors of remission and low disease activity in Latin American early rheumatoid arthritis: data from the GLADAR cohort

Abstract:

Objectives: To identify baseline pbkp_redictors of remission and low disease activity (LDA) in early rheumatoid arthritis (RA) from the GLADAR (Grupo Latino Americano De estudio de la Artritis Reumatoide) cohort. Methods: Patients with 1- and 2-year follow-up visits were included. Remission and LDA were defined by DAS28-ESR (< 2.6 and ≤ 3.2, respectively). Baseline pbkp_redictors examined were gender, ethnicity, age at diagnosis, socioeconomic status, symptoms’ duration, DMARDs, RF, thrombocytosis, anemia, morning stiffness, DAS28-ESR (and its components), HAQ-DI, DMARDs and corticosteroid use, and Sharp-VDH score. Multivariable binary logistic regression models (excluding DAS28-ESR components to avoid over adjustment) were derived using a backward selection method (α-level set at 0.05). Results: Four hundred ninety-eight patients were included. Remission and LDA/remission were met by 19.3% and 32.5% at the 1-year visit, respectively. For the 280 patients followed for 2 years, these outcomes were met by 24.3% and 38.9%, respectively. Pbkp_redictors of remission at 1 year were a lower DAS28-ESR (OR 1.17; CI 1.07–1.27; p = 0.001) and HAQ-DI (OR 1.48; CI 1.04–2.10; p = 0.028). At 2 years, only DAS28-ESR (OR 1.40; CI 1.17–1.6; p < 0.001) was a pbkp_redictor. Pbkp_redictors of LDA/remission at 1 year were DAS28-ESR (OR 1.42; CI 1.26–1.61; p < 0.001), non-use of corticosteroid (OR 1.74; CI 1.11–2.44; p = 0.008), and male gender (OR 1.77; CI 1.2–2.63; p = 0.036). A lower baseline DAS28-ESR (OR 1.45; CI 1.23–1.70; p < 0.001) was the only pbkp_redictor of LDA/remission at 2 years. Conclusions: A lower disease activity consistently pbkp_redicted remission and LDA/remission at 1 and 2 years of follow-up in early RA patients from the GLADAR cohort.Key Points• In patients with early RA, a lower disease activity at first visit is a strong clinical pbkp_redictor of achieving remission and LDA subsequently.• Other clinical pbkp_redictors of remission and LDA to keep in mind in these patients are male gender, non-use of corticosteroids and low disability at baseline.• Not using corticosteroids at first visit is associated with a lower disease activity and pbkp_redicts LDA/remission at 1 year in these patients.

Año de publicación:

2019

Keywords:

• Early RA outcomes
• Early RA remission
• Early RA response pbkp_redictors
• Latin America early RA

Fuente:

scopus