Clinicopathologic significance of BRAF mutation in papillary thyroid carcinoma

Abstract:

Background: Thyroid carcinoma is the most common endocrine malignancy. BRAF (V600E) mutation is the most frequent detected genetic change in papillary thyroid carcinomas (PTC). There are some discrepancies regarding the overall frequency of the mutation, its prevalence in PTC-variants and its relationship with clinicopathological parameters of poor outcome. Aims: To investigate the relationship of clinicopathological features of PTC with BRAF mutation with particular reference to histological subtype. Patients and methods: We analysed 97 patients (77.3% female, mean follow up 33.9±26.7 months) with pathological diagnosis of PTC. DNA was extracted from tissues blocks or fresh tissue and BRAF (V600E) mutations were detected by PCR and sequencing. Univariate (χ 2 and Student’s t test) and multivariate analysis were realised. Results: BRAF (V600E) was detected in 45.4% of the study group. The …

Año de publicación:

2011

Keywords:

Fuente:

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