Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates

Abstract:

(Figure Presented) Herein we report a novel targeted drug delivery system consisting of nanoparticle-aptamer bioconjugates,which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Año de publicación:

2007

Keywords:

• conjugation
• Nanoparticles
• Antitumor agents
• Dual drug delivery
• Targeted therapy

Fuente:

scopus