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Combination of vitamin supplementation and regular exercise as the best option to antioxidant status in emotional stressed rats

Abstract:

The study was designed to determine whether the association of regular exercise and vitamin supplementation may be a better alternative than single exercise to reduce oxidative damage induced by emotional stress by of increasing antioxidant status. Forty 1-month-old male albino Wistar rats were used in this experimental study distributed into two groups as Stressed/Exercised (lot A; n=20) and Stressed/Exercised/Dietary Supplemented (lot B; n =20). Animals were stressed 1 h/day, 5 days a week for 8 weeks by placing them in a 25 × 7 cm plastic bottle adjusting it with platter tape on the outside so that the animal was unable to move. Swimming, used as the moderate exercise for the trained rats was applied 5 days a week for 8 weeks. Rats from group B were treated with dietary supplements of both antioxidant vitamin E and C. Plasmatic total antioxidant status (TAS) was determined using commercial test kits supplied by Randox laboratories. We found significant differences regarding TAS between rats from lot A and B (0.73±0.02 vs 0.94±0.04; p=0.0176). Consequently, our results highlight the potential benefit of combined regular exercise and vitamin supplementation to attenuate oxidative damage compared with that achieved by single exercise. Further studies concerning other variables and tissues are required for a better understanding of the influence of both moderate exercise and vitamin supplementation in oxidative damage induced by emotional stress. Copyright © Hellenic Society of Haematology.