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Comparative gastroprotective activity of Malva pseudolavatera webb & Berthel and Malva sylvestris L. Grown in Ecuador

Abstract:

Species of the genus Malva (Malva pseudolavatera and Malva sylvestris), introduced in Ecuador, are widely used traditionally. However, unlike the species M. sylvestris, for M. pseudolavatera there is no information on its composition and properties. The species were collected in the province of Chimborazo Ecuador. Aqueous decoction extracts were made which were lyophilized to obtain dry extracts. Gastroprotective activity was studied in two models of ulcers induced by ethanol and NSAIDs (ASA). Male mice with average weights of 30 ± 2 g were used, which were divided into 13 groups of 5 mice, for each of the models. The treatments of aqueous extracts of M. pseudolavatera and M. sylvestris were administered orally, for seven days, in doses of 1000, 500, 250, 125 and 75 mg / Kg of mouse weight respectively. The degree of gastric protection was compared between the two species studied and it was evidenced that at the dose of 1000 mg / kg, M. pseudolavatera presented greater gastric protection than M. sylvestris, which was met at lower doses for the two models used. The inhibition percentages of gastric ulcers showed that the positive control treated with Sucralfate reached 87.5% inhibition, while the groups treated with the extracts of M. pseudolavatera and M. sylvestris at doses of 1000 mg / Kg reached 77 and 72%. inhibition respectively in the induction model alcohol and 84 and 78% inhibition respectively in the induction model NSAID.