Comparing ultrasonic and breath-actuated jet nebulisers for sputum induction

Abstract:

Background: Sputum induction is an established non-invasive approach to assess airway inflammation. Ultrasonic nebulisers (UN) are typically used for sputum induction but new breath-actuated jet nebulisers (BAN) may have benefits in terms of patient experience and sample acquisition. Aim: To compare the success rate, safety and quality of sputum samples induced by UN and BAN. Methods: This was a single-site crossover study including patients with stable asthma or COPD, randomised to use BAN (Vectura - Akita Jet) at visit 1 and UN (Omron - NEU-17) at visit 2 or vice versa. Tests with both devices were performed with 4.5% saline solution with measures of BORG scale, O2 saturation and FEV1 performed after each induction. Samples were processed as per standard protocols and cytospin slides prepared. Results: 35 patients were recruited (60% male, median age 66). There were 18 (51%) successful …

Año de publicación:

2022

Keywords:

Fuente:

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