Comparison of two regimens of oral clindamycin versus dicloxacillin in the treatment of mild-to-moderate skin and soft-tissue infections

Abstract:

This prospective, double-masked, randomized study was performed in 14 centers throughout Asia (The Philippines and Thailand), Latin America (Mexico, Peru, Chile, and Venezuela), and Europe (Poland, Hungary, and the Czech Republic). Outpatients with acute mild-to-moderate skin and soft-tissue infections (cellulitis, impetigo, folliculitis, furunculosis and carbuncles without surgical incision, and skin wound infections from trauma) were randomly assigned to one of the following regimens for a total of 7 to 14 days: (1) clindamycin 150 mg four times daily (QID) (CLIN 150); (2) clindamycin 300 mg twice daily (BID) (CLIN 300); or (3) dicloxacillin 250 mg QID (DICLOX). Patients were assessed clinically and bacteriologically at the end of treatment and 2 to 3 weeks after treatment. Study variables included clinical and bacteriologic outcomes. No statistically significant differences in any of the study variables were noted …

Año de publicación:

1998

Keywords:

Fuente:

google