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Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Abstract:

We report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1). We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR, and NF1. Integrated analysis classified PCCs/PGLs into four molecularly defined groups: a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortical admixture subtype. Correlates of metastatic PCCs/PGLs included the MAML3 fusion gene. This integrated molecular characterization provides a comprehensive foundation for developing PCC/PGL precision medicine.

Año de publicación:

2017

Keywords:

  • expression subtypes
  • CSDE1
  • MAML3
  • Paraganglioma
  • TCGA
  • Sequencing
  • pheochromocytoma
  • Metástasis
  • molecular profiling
  • Genomics

Fuente:

scopusscopus

Tipo de documento:

Article

Estado:

Acceso abierto

Áreas de conocimiento:

  • Patología
  • Biología molecular
  • Bioquímica

Áreas temáticas:

  • Farmacología y terapéutica
  • Enfermedades

Contribuidores:

Chudamani S.Chudamani S.
Rathmell W.K.Rathmell W.K.
Gimenez-Roqueplo A.P.Gimenez-Roqueplo A.P.
Holt R.A.Holt R.A.
Haussler D.Haussler D.
Fishbein L.Fishbein L.
Ling S.Ling S.
Hantel C.Hantel C.
Balasundaram M.Balasundaram M.
Wenz B.Wenz B.
Ferguson M.L.Ferguson M.L.
Gastier-Foster J.M.Gastier-Foster J.M.
Kebebew E.Kebebew E.
Bowlby R.Bowlby R.
Getz G.Getz G.
Fiddes I.Fiddes I.
Gerken M.Gerken M.
Gupta M.Gupta M.
Deutschbein T.Deutschbein T.
Tischler A.S.Tischler A.S.
Lawrence M.S.Lawrence M.S.
Benz C.Benz C.
Goldman M.Goldman M.
Lechan R.Lechan R.
Brooks D.Brooks D.
Arachchi H.Arachchi H.
Graim K.Graim K.
Chin L.Chin L.
Balu S.Balu S.
Carlsen R.Carlsen R.
Auman J.T.Auman J.T.
Gabriel S.B.Gabriel S.B.
Bauer T.Bauer T.
Cho J.Cho J.
Hoadley K.A.Hoadley K.A.
Ally A.Ally A.
Cherniack A.D.Cherniack A.D.
Richard J. AuchusRichard J. Auchus
Bartsch D.K.Bartsch D.K.
Danilova L.Danilova L.
Gehlenborg N.Gehlenborg N.
De Cubas A.A.De Cubas A.A.
Crain D.Crain D.
Amelio A.L.Amelio A.L.
Leshchiner I.Leshchiner I.
Eschbacher J.Eschbacher J.
Korpershoek E.Korpershoek E.
Kimes P.Kimes P.
Huang M.Huang M.
Bodenheimer T.Bodenheimer T.
Jones S.J.M.Jones S.J.M.
de Krijger R.R.de Krijger R.R.
Felau I.Felau I.
Jefferys S.R.Jefferys S.R.
Beuschlein F.Beuschlein F.
Heiman D.I.Heiman D.I.
Kasaian K.Kasaian K.
Hunt B.Hunt B.
Robertson A.G.Robertson A.G.
Lichtenberg T.M.Lichtenberg T.M.
Chuah E.Chuah E.
Hahner S.Hahner S.
Cope L.Cope L.
Lander E.Lander E.
Jones C.D.Jones C.D.
Carter S.Carter S.
Hutter C.M.Hutter C.M.
Haan D.Haan D.
Baudin E.Baudin E.
Frazer S.Frazer S.
Geurts J.Geurts J.
Cassol C.A.Cassol C.A.
Curley E.Curley E.
Akbani R.Akbani R.
Johnson A.R.Johnson A.R.
Gardner J.Gardner J.
Demchok J.A.Demchok J.A.
Beroukhim R.Beroukhim R.
Dhalla N.Dhalla N.
Bowen J.Bowen J.
Murray B.A.Murray B.A.
Kim J.Kim J.
Hayes D.N.Hayes D.N.
Dinjens W.N.M.Dinjens W.N.M.
Walter V.Walter V.
Eng C.Eng C.
Boice L.Boice L.
Beaver A.Beaver A.
Knijnenburg T.Knijnenburg T.
Makowski L.Makowski L.
Giordano T.J.Giordano T.J.
Asa S.L.Asa S.L.
Feldman M.Feldman M.
Fassnacht M.Fassnacht M.
Ghayee H.K.Ghayee H.K.
Dimmock D.Dimmock D.
Baertsch R.Baertsch R.
Else T.Else T.
Hoyle A.P.Hoyle A.P.
Amar L.Amar L.