Cord blood manganese and teacher-reported ADHD-related behaviors among 8-year old children

Abstract:

Background: Manganese (Mn) is a naturally occurring metal to which humans are commonly exposed. Though an essential nutrient, exposure to high levels of Mn is associated with neurotoxicity. Animal studies show alterations in dopaminergic function in relation to high neonatal Mn levels, providing evidence for a potential link with Attention Deficit Hyperactivity Disorder (ADHD). Aims: To investigate the association of cord blood Mn with teacher-reported ADHD-related behaviors among children at 8 years of age. Methods: We enrolled 788 mother-infant pairs in a prospective birth cohort. Children were born 1993-1998 to mothers residing adjacent to a metal- and PCB-contaminated harbor in New Bedford, Massachusetts. We measured umbilical cord blood Mn levels using inductively coupled plasma-mass spectrometry (ICP-MS) and fit multivariable regression models to estimate associations with teacher-reported …

Año de publicación:

2013

Keywords:

Fuente:

google