Cp<inf>2</inf>TiCl-catalyzed, concise synthetic approach to marine natural product (±)-cyclozonarone

Abstract:

A concise synthetic approach to the bioactive marine natural product (±)-cyclozonarone has been reported from readily available epoxy-farnesol acetate. Key steps of this protocol include Cp2TiCl-catalyzed radical cascade cyclization of an epoxy-farnesol derivative and a Diels–Alder reaction between a 1,3-diene and p-benzoquinone.

Año de publicación:

2019

Keywords:

• Natural products
• Green Chemistry
• Cyclozonarone
• Titanocene
• radical chemistry
• diastereoselective synthesis

Fuente:

scopus