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Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8
ArticleAbstract: The senescence-accelerated strains of mice (SAMP) are well-characterized animal models of senescencePalabras claves:Calpain, Catalase, Neurodegeneration, Oxidative Stress, Senescence, TauAutores:Antoni Camins, Canudas A.M., Gutiérrez-Cuesta J., Mallol J., Mulero M., Pallás M., Romeu M., Sureda F.X.Fuentes:scopusBehaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence
ArticleAbstract: Senescence accelerated mice P8 (SAMP8) is a phenotypic model of age, characterized by deficits in mePalabras claves:ageing, Behaviour, COGNITION, inflammation, Learning, Neurodegeneration, Oxidative StressAutores:Aguado F., Antoni Camins, Griñan-Ferré C., Pallás M., Palomera-ávalos V., Plá V., Porquet D., Puigoriol-Illamola D.Fuentes:scopusAn evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis
ArticleAbstract: The neuroprotective effects of melatonin in an experimental model of aging-induced apoptosis have bePalabras claves:aging, cell cycle, Neurodegeneration, P53Autores:Antoni Camins, Pallás M., Pelegrí Gabalda C., Tajes Orduña M., Vilaplana J.Fuentes:scopusAnti-aging properties of melatonin in an in vitro murine senescence model: Involvement of the sirtuin 1 pathway
ArticleAbstract: Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerabPalabras claves:ADAM10, aging, Neurodegeneration, NFκB, Oxidative Stress, P53Autores:Antoni Camins, Gutiérrez-Cuesta J., Ortuo-Sahagún D., Pallás M., Tajes M.Fuentes:scopusA chronological review of potential disease-modifying therapeutic strategies for Alzheimer's disease
ReviewAbstract: Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that has become a worldwide hePalabras claves:Alzheimer’s disease, calcium, ER stress, glutamate, Neurodegeneration, neuroinflammation, Oxidative Stress, Parkinson’s DiseaseAutores:Antoni Camins, Auladell C., Busquets O., Espinosa-Jimenez T., Ettcheto M., Verdaguer E.Fuentes:scopusA single dose of pirfenidone attenuates neuronal loss and reduces lipid peroxidation after kainic acid-induced excitotoxicity in the pubescent rat hippocampus
ArticleAbstract: Systemic administration of kainic acid (KA) in rodents triggers limbic seizures following selectivePalabras claves:4-Hydroxynonenal (4-HNE), Kainic Acid Model, Neurodegeneration, neuroprotection, PirfenidoneAutores:Antoni Camins, Armendáriz-Borunda J., Bañuelos-Pineda J., Castro-Torres R.D., Chaparro-Huerta V., Flores-Soto M.E., Orozco-Suárez S.A., Zárate C.B.Fuentes:scopusCalpains as a target for therapy of neurodegenerative diseases: Putative role of lithium
ReviewAbstract: Lithium is a simple cation that has been used clinically since 1950 for the treatment of bipolar disPalabras claves:apoptosis, Calcium homeostasis, Calpain, Cell cycle control, Cytoskeleton, DNA damage, Kinases, Lithium, Neurodegeneration, neurodegenerative diseases, signal transduction, Tau kinasesAutores:Antoni Camins, Canudas A.M., Crespo-Biel N., Junyent F., Pallás M., Verdaguer E.Fuentes:scopusCarbonyl stress and NMDA receptor activation contribute to methylglyoxal neurotoxicity
ArticleAbstract: Methylglyoxal (MG) is a reactive α-ketoaldehyde physiologically generated as a by-product of glycolyPalabras claves:Carbonyl stress, Free radicals, methylglyoxal, Mitochondria, Neurodegeneration, NMDA receptorsAutores:Allgaier C., Antoni Camins, Garcia De Arriba S., García-Jordà E., Krügel U., Lewerenz A., Münch G., Nieber K., Pallás M., Regenthal R., Verdaguer E., Vissiennon Z.Fuentes:scopusActivation of Akt by lithium: Pro-survival pathways in aging
ArticleAbstract: The effects of lithium on senescence were investigated using the senescence-accelerated mouse pronePalabras claves:aging, Lithium chloride, Neurodegeneration, neuroprotection, SAMP8Autores:Antoni Camins, Casadesús G., Chou S.P., Pallás M., Smith M.A., Tajes M., Yeste-Velasco M., Zhu X.Fuentes:scopusGene expression profile in JNK3 null mice: A novel specific activation of the PI3K/AKT pathway
ArticleAbstract: JNK3 is mainly expressed in the CNS and it plays a crucial role in neuronal death in several neurodePalabras claves:Akt, Gene profiling, JNK, Neurodegeneration, neuroprotection, PI3KAutores:Antoni Camins, Auladell C., De Lemos M.L., Ferrer I., Folch J., Junyent F., Ortuo-Sahagún D., Pallás M., Romero R., Verdaguer E., Zárate C.B.Fuentes:scopus