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Amide-to-ester substitution allows fine-tuning of the cyclopeptide conformational ensemble
ArticleAbstract: (Figure Presented) Without affecting the overall 3D structure, amide-to-ester backbone substitutionPalabras claves:Bioorganic chemistry, Conformation analysis, Depsipeptides, Molecular dynamicsNMR spectroscopyAutores:Adan J., Alberício F., Cupido T., Jan Spengler, Mitjans F., Piulats J., Ruíz-Rodríguez J.Fuentes:scopusTackling lipophilicity of peptide drugs: Replacement of the backbone n -methyl group of Cilengitide by N -oligoethylene glycol (N -OEG) chains
ArticleAbstract: Cilengitide is an RGD-peptide of sequence cyclo[RGDfNMeV] that was was developed as a highly activePalabras claves:Autores:Adan J., Alberício F., Fernandez-Llamazares A.I., Jan Spengler, Mitjans F.Fuentes:googlescopusThe backbone N-(4-azidobutyl) linker for the preparation of peptide chimera
ArticleAbstract: A robust synthetic strategy for the introduction of the N-(4-azidobutyl) linker into peptides usingPalabras claves:Autores:Adan J., Alberício F., Fernandez-Llamazares A.I., García J., Jan Spengler, Meunier D., Mitjans F.Fuentes:googlescopus