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Towards a unifying mechanism for CYP17 mutations that cause isolated 17, 20-lyase deficiency
Conference ObjectAbstract: Cytochrome P450c17 (CYP17) is a single hemoprotein that catalyzes both the 17x-hydroxylase and 17, 2Palabras claves:Autores:Gupta M.K., Richard J. AuchusFuentes:scopusWhy human cytochrome P450c21 is a progesterone 21-hydroxylase
ArticleAbstract: Human cytochrome P450c21 (steroid 21-hydroxylase, CYP21A2) catalyzes the 21-hydroxylation of progestPalabras claves:Autores:Dwyer C., Gupta M.K., Mizrachi D., Richard J. Auchus, Sharma K.K., Wang Z., Xu K.Fuentes:scopusThe enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21
ArticleAbstract: Human cytochrome P450c17 (17α-hydroxylase, 17,20-lyase) (CYP17) and cytochrome P450c21 (21-hydroxylaPalabras claves:17α-Hydroxylase/17,20-lyase, 21-hydroxylase, CYP17, CYP21, Cytochrome P450c17, Cytochrome P450c21, ent-Progesterone, Enzyme inhibition, molecular dynamics, Type I difference spectrumAutores:Boswell C., Bruce K., Covey D.F., Gupta M.K., Kumar A., Rath N., Richard J. AuchusFuentes:scopus