Mostrando 2 resultados de: 2
5α-reduced C<inf>21</inf> steroids are substrates for human cytochrome P450c17
ArticleAbstract: The 5α-reduction of testosterone in target tissues is a key step in androgen physiology; however, 5αPalabras claves:17-hydroxylase/17,20-lyase, 3α-Hydroxysteroid dehydrogenase, 5α-reductase, Allopregnanolone, Androstanediol, CYP17, Cytochrome b 5, Dihydrotestosterone, P450c17, Sexual differentiationAutores:Gupta M.K., Guryev O.L., Richard J. AuchusFuentes:scopusThe enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21
ArticleAbstract: Human cytochrome P450c17 (17α-hydroxylase, 17,20-lyase) (CYP17) and cytochrome P450c21 (21-hydroxylaPalabras claves:17α-Hydroxylase/17,20-lyase, 21-hydroxylase, CYP17, CYP21, Cytochrome P450c17, Cytochrome P450c21, ent-Progesterone, Enzyme inhibition, molecular dynamics, Type I difference spectrumAutores:Boswell C., Bruce K., Covey D.F., Gupta M.K., Kumar A., Rath N., Richard J. AuchusFuentes:scopus