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C-Jun N-Terminal Kinases in Alzheimer's Disease: A Possible Target for the Modulation of the Earliest Alterations
ReviewAbstract: Given the highly multifactorial origin of Alzheimer's disease (AD) neuropathology, disentangling andPalabras claves:Alzheimer's disease, Amyloid-β, axonal transport, hyperphosphorylated tau, JNK, synapse lossAutores:Antoni Camins, Auladell C., Busquets O., Castro-Torres R.D., Ettcheto M., Parcerisas A., Verdaguer E., Zárate C.B.Fuentes:scopusAntiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells
ArticleAbstract: In the present study dopaminergic neuroblastoma B65 cells were exposed to Camptothecin (CPT) (0.5-10Palabras claves:Ataxia telangiectasia mutated, camptothecin, cell cycle, RoscovitineAutores:Antoni Camins, Auladell C., Folch J., Junyent F., Pallás M., Pizarro J.G., Verdaguer E., Zárate C.B.Fuentes:scopusGene expression profile in JNK3 null mice: A novel specific activation of the PI3K/AKT pathway
ArticleAbstract: JNK3 is mainly expressed in the CNS and it plays a crucial role in neuronal death in several neurodePalabras claves:Akt, Gene profiling, JNK, Neurodegeneration, neuroprotection, PI3KAutores:Antoni Camins, Auladell C., De Lemos M.L., Ferrer I., Folch J., Junyent F., Ortuo-Sahagún D., Pallás M., Romero R., Verdaguer E., Zárate C.B.Fuentes:scopusEpigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice
ArticleAbstract: Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated fPalabras claves:APPswe/PS1dE9 mice, Cognitive deficits, Epigallocatechin-3-gallate, hippocampus, obesity, unfolded protein responseAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Castro-Torres R.D., Ettcheto M., Folch J., García M.L., Manzine P.R., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusEvaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer’s Disease
ArticleAbstract: c-Jun N-terminal kinases (JNKs), which belong to a mitogen-activated protein kinase (MAPK) family, aPalabras claves:Alzheimer’s disease, amyloid, Amyloid precursor protein, APPswe/PS1dE9, BACE1, JNK1, PGC-1α, Transgenic mouse models, β-secretase, βAAutores:Abad S., Antoni Camins, Auladell C., Ettcheto M., Folch J., Luque M., Pallás M., Pedros I., Petrov D., Verdaguer E.Fuentes:scopusDual mkk4 and mkk7 gene deletion in adult mouse causes an impairment of hippocampal immature granule cells
ArticleAbstract: (1) Background: The c-Jun-NH2-terminal protein kinase (JNK) is a mitogen-activated protein kinase inPalabras claves:Cre-LoxP, DCX, hippocampus, MKK4, MKK7, PJNKAutores:Antoni Camins, Auladell C., Caruana P., Castro-Torres R.D., Ettcheto M., Leighton K.M., Olloquequi J., Steele L., Ureña J., Verdaguer E., Zárate C.B.Fuentes:scopusSirtuin activators: Designing molecules to extend life span
ReviewAbstract: Resveratrol (RESV) exerts important pharmacological effects on human health: in addition to its benePalabras claves:DIABÉTES, neurodegenerative diseases, Resveratrol, Sirtuin activators, SirtuinsAutores:Antoni Camins, Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Sureda F.X., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusc-Jun N-terminal Kinase 1 ablation protects against metabolic-induced hippocampal cognitive impairments
ArticleAbstract: Abstract: The development of metabolic alterations like insulin resistance has been associated withPalabras claves:c-Jun N-terminal Kinase 1, Cognitive impairments, high-fat dietAutores:Antoni Camins, Auladell C., Bulló M., Busquets O., Casadesús G., Castro-Torres R.D., Eritja À., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusRole of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration
ReviewAbstract: Chemoconvulsants that induce status epilepticus in rodents have been widely used over the past decadPalabras claves:apoptosis, C-Jun N-terminal kinase signaling pathway, hippocampus, Kainic acid, neuroprotection, ReviewAutores:Antoni Camins, Auladell C., Busquets O., De Lemos M.L., Ettcheto M., Folch J., Lazarowski A., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusRole of cdk5 on ATM phosphorylation in neuronal death induced by DNA damage
ArticleAbstract: This study demonstrates that Cdk5 phosphorylates ataxia-telangiectasia mutated protein (ATM) at Ser7Palabras claves:Autores:Antoni Camins, Junyent F., Pallás M., Verdaguer E.Fuentes:scopus