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Drug Metabolism and Drug Interactions(2)
Drug Metabolism and Personalized Therapy(2)
Translational Psychiatry(2)
Biomedical Reports(1)
Current Topics in Medicinal Chemistry(1)
Clinical implementation of pharmacogenetics and personalized drug prescription based on e-health: The MedeA initiative
ArticleAbstract:Palabras claves:Autores:Adrián LLerena, Cobaleda J., de Andrés F., Mata-Martín C., Penãs-Lledó E.M., Pijierro A., Sánchez C.L.Fuentes:scopusA one-year follow-up study of treatment-compliant suicide attempt survivors: relationship of CYP2D6-CYP2C19 and polypharmacy with suicide reattempts
ArticleAbstract: This study of a cohort of 1-year treatment-compliant survivors of a suicide attempt examined for thePalabras claves:Autores:Adrián LLerena, Cortés-Martínez A., Courtet P., de Andrés F., Dubois J., Guillaume S., Kahn J.P., Leboyer M., Olié E., Penãs-Lledó E.M.Fuentes:scopusCurrent insights into interethnic variability in testicular cancers: Population pharmacogenetics, clinical trials, genetic basis of chemotherapyinduced toxicities and molecular signal transduction
ReviewAbstract: Testicular cancer is an aggressive malignancy with a rising incidence rate across the globe. TesticuPalabras claves:clinical trials, ethnicity, Molecular aspects, pharmacogenetics, Pharmacogenomics, population pharmacogenetics, Precision Medicine, signal transduction, Testicular cancer, Testicular seminoma, Toxicity, Variant polymorphismAutores:Adrián LLerena, de Andrés F., Kothari R., Mishra A., Nair S., Vasistha A.Fuentes:scopusCurrent perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction
ArticleAbstract: Multiple myeloma (MM) is an aggressive cancer characterised by malignancy of the plasma cells and aPalabras claves:Cáncer, Drug resistance, Interethnic variability, Molecular aspects, Multiple myeloma, population pharmacogenetics, Precision Medicine, signal transductionAutores:Adrián LLerena, Bakhai V., de Andrés F., Gandhi M., Mishra A., Nair S., Sharma R., Trivedi J.Fuentes:scopusFrequency of CYP2C9 (*2, *3 and IVS8-109A>T) allelic variants, and their clinical implications, among mexican patients with diabetes mellitus type 2 undergoing treatment with glibenclamide and metformin
ArticleAbstract: The majority of Mexican patients with diabetes mellitus type 2 (DMT2) (67.9-85.0%) are prescribed suPalabras claves:Cytochrome P450 2C9, DIABÉTES, Glibenclamide, Glycated hemoglobin A1c, MetforminAutores:Adrián LLerena, Castillo-Nájera F., Cuautle-Rodríguez P., de Andrés F., Molina-Guarneros J.A., Rodríguez-Rivera N.S.Fuentes:scopusEvaluation of drug-metabolizing enzyme hydroxylation phenotypes in Hispanic populations: The CEIBA cocktail
ReviewAbstract: Interindividual differences in response to drug treatments are mainly caused by differences in drugPalabras claves:Cocktail, Cytochrome P450 (CYP), Genotype, Hispanics, PhenotypeAutores:Adrián LLerena, Alonso-Vilatela E., Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Ferreiro V., Fiedler J., Francisco J.López Hernández, Galaviz-Hernandez C., Garza-Ocañas L., González-Vacarezza N., Grazina M., Herrera L., Jiménez-Arce G., Lares-Asseff I., Lazalde-Ramos B.P., Leonardo J. Beltrán, López-López M., Monroy-Jaramillo N., Moya G.E., Naranjo M.E.G., Natalia Heras, Ochoa-Morales A., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., Rodeiro I., Rojas-Martinez A., Rojas-Ponce R., Sarmiento A.P., Sosa-Macías M.G., Tarazona-Santos E.M., Vázquez T.C., Yescas-Gómez P.Fuentes:scopusMultiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach
ArticleAbstract: Phenotyping of the CYP450 enzyme activities contributes to personalized medicine, but the past phenoPalabras claves:Autores:Adrián LLerena, Bovera M., de Andrés F., Enrique Terán, Humberto Fariñas, Santiago TeránFuentes:googlescopusPharmacogenetics in Latin American populations: Regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders
Conference ObjectAbstract: Meeting report of the " Second Symposium on Pharmacology of Cytochrome P450 and Transporters " organPalabras claves:Cytochrome p450, Hispanics, Latin America, pharmacogeneticsAutores:Adrián LLerena, Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Doredo P., ElisaAlonso M., Enrique Terán, Estévez-Carrizo F.E., Ferrero V., Fiedler J., Francisco J.López Hernández, Galaviz-Hernandez C., García-Mesa M., Garza-Ocañas L., González-Naranjo M.E., González-Vacarezza N., Grazina M., Herrera L., Jiménez-Arce G., Lares-Asseff I., Lazalde B., Leonardo J. Beltrán, López-López M., Monroy-Jaramillo N., Moya G.E., Natalia Heras, Ochoa-Morales A., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., Remírez-Figueredo D., Rodeiro I., Rojas-Martinez A., Rojas-Ponce R., Sarmiento-Sánchez A.P., Sosa-Macías M.G., Tarazona-Santos E.M., Vázquez T.C., Yescas-Gómez P.Fuentes:scopusPharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients
ArticleAbstract: Mexico has been under official epidemiological alert due to diabetes since 2016. This study presentsPalabras claves:Diabetes type 2, Metformin, pharmacogenetics, sulphonylureas, therapeutic inefficacy, TransportersAutores:Adrián LLerena, de Andrés F., Espinosa-Sánchez A.G., Molina-Guarneros J.A., Ortega-Ayala A., Pérez-Silva E., Rodríguez-Rivera N.S.Fuentes:scopusVEGF-related polymorphisms identified by GWAS and risk for major depression
ArticleAbstract: Depression is a common, severe, disabling mental disease that affects millions of people of all agesPalabras claves:Autores:Adrián LLerena, Cobaleda J., de Andrés F., Delgado A., Lamont J., Martin M., Murray H., Penãs-Lledó E.M., Siest G., Stathopoulou M.G., Visvikis-Siest S., Xie T.Fuentes:scopus