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OMICS A Journal of Integrative Biology(2)
Pharmacogenomics Journal(2)
Current Pharmaceutical Biotechnology(1)
Expert Opinion on Drug Metabolism and Toxicology(1)
Journal of Clinical Psychopharmacology(1)
Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach
ArticleAbstract: Phenotyping of the CYP450 enzyme activities contributes to personalized medicine, but the past phenoPalabras claves:Autores:Adrián LLerena, Bovera M., de Andrés F., Enrique Terán, Humberto Fariñas, Santiago TeránFuentes:googlescopusInterethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and pbkp_redicted drug metabolism phenotypes among 6060 ibero-and native Americans: RIBEF-CEIBA consortium report on population pharmacogenomics
ArticleAbstract: Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of gPalabras claves:Amerindians, CYP2C19, CYP2C9, CYP2D6, drug metabolism, LATIN AMERICANS, pharmacogenetics, Precision MedicineAutores:Adrián LLerena, Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Fcrreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Gilman R.H., Gouveia M.H., Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Monroy-Jaramillo N., Moya G.E., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Santiago Terán, Sarmiento A.P., Scliar M.O., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Zamudio R.Fuentes:googlescopusInterethnic variation of CYP2C19 alleles, 'pbkp_redicted' phenotypes and 'measured' metabolic phenotypes across world populations
ReviewAbstract: The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and CYP2C19 metaPalabras claves:Autores:Adrián LLerena, Céspedes-Garro C., de Andrés F., Delgado A., Fricke-Galindo I., López-López M., Naranjo M.E.G., Penãs-Lledó E.M., Rodrigues-Soares F.Fuentes:scopusPharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients
ArticleAbstract: Mexico has been under official epidemiological alert due to diabetes since 2016. This study presentsPalabras claves:Diabetes type 2, Metformin, pharmacogenetics, sulphonylureas, therapeutic inefficacy, TransportersAutores:Adrián LLerena, de Andrés F., Espinosa-Sánchez A.G., Molina-Guarneros J.A., Ortega-Ayala A., Pérez-Silva E., Rodríguez-Rivera N.S.Fuentes:scopusSimultaneous determination of cytochrome P450 oxidation capacity in humans: A review on the phenotyping cocktail approach
ReviewAbstract: Intra-and/or inter-individual variability in drug response is mainly a result of either subtherapeutPalabras claves:Cocktail, Cytochrome p450, drug metabolism, In vivo, Phenotype, Probe drug, SelectiveAutores:Adrián LLerena, de Andrés F.Fuentes:scopusWorldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes
ReviewAbstract: Introduction: Notably differences in CYP2C9 allele frequencies among worldwide populations have beenPalabras claves:CYP2C9, ethnicity, Genotype, PhenotypeAutores:Adrián LLerena, Céspedes-Garro C., de Andrés F., Fricke-Galindo I., Humberto Fariñas, López-López M., Naranjo M.E.G., Penãs-Lledó E.M., Rodrigues-Soares F.Fuentes:scopusRelationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population
ArticleAbstract: Interethnic variability in the drug-metabolizing capacity of CYP450 enzymes may lead to discrepanciePalabras claves:Autores:Adrián LLerena, Altamirano-Tinoco C., de Andrés F., Dorado P., Montes-Mondragón C.F., Penãs-Lledó E.M., Ramírez-Roa R.Fuentes:scopusThe psychostimulant khat (Catha edulis) inhibits CYP2D6 enzyme activity in humans
ArticleAbstract: The use of khat (Catha edulis) while on medication may alter treatment outcome. In particular, the iPalabras claves:cathine, cathinone, CYP2D6, dextromethorphan, drug interaction, khatAutores:Adrián LLerena, Aklillu E., Beck O., Bedada W., Bertilsson L., de Andrés F., Engidawork E., Pohanka A.Fuentes:scopus