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OMICS A Journal of Integrative Biology(2)
Pharmacogenomics Journal(2)
Current Pharmaceutical Biotechnology(1)
Drug Metabolism and Personalized Therapy(1)
Journal of Pharmacy and Pharmaceutical Sciences(1)
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Farmacología y terapéutica(4)
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Can the CEIBA cocktail designed for human cytochrome P450 enzymes be used in the rat for drug interaction studies?
ArticleAbstract: Purpose - The CEIBA cocktail consisting of caffeine (CAF), omeprazole (OZ), dextromethorphan (DM) anPalabras claves:Autores:Adrián LLerena, Alves G., de Andrés F., Falcao A.C., Magalhães P.Fuentes:scopusHigh frequency of CYP2D6 ultrarapid metabolizers in Spain: Controversy about their misclassification in worldwide population studies
ArticleAbstract: A high frequency (7-10%) of CYP2D6 ultrarapid metabolizers estimated from the genotype (gUMs) has bePalabras claves:Autores:Adrián LLerena, Cobaleda J., de Andrés F., Delgado A., Naranjo M.E.G., Penãs-Lledó E.M.Fuentes:scopusInterethnic variation of CYP2C19 alleles, 'predicted' phenotypes and 'measured' metabolic phenotypes across world populations
ReviewAbstract: The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and CYP2C19 metaPalabras claves:Autores:Adrián LLerena, Céspedes-Garro C., de Andrés F., Delgado A., Fricke-Galindo I., López-López M., Naranjo M.E.G., Penãs-Lledó E.M., Rodrigues-Soares F.Fuentes:scopusMultiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach
ArticleAbstract: Phenotyping of the CYP450 enzyme activities contributes to personalized medicine, but the past phenoPalabras claves:Autores:Adrián LLerena, Bovera M., de Andrés F., Enrique Terán, Humberto Fariñas, Santiago TeránFuentes:googlescopusSimultaneous determination of cytochrome P450 oxidation capacity in humans: A review on the phenotyping cocktail approach
ReviewAbstract: Intra-and/or inter-individual variability in drug response is mainly a result of either subtherapeutPalabras claves:Cocktail, Cytochrome p450, drug metabolism, In vivo, Phenotype, Probe drug, SelectiveAutores:Adrián LLerena, de Andrés F.Fuentes:scopusRelevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population
ArticleAbstract: CYP2C9, CYP2C19 and CYP2D6 metabolize around 40 % of drugs and their genes vary across populations.Palabras claves:Afro-Caribbean, Amerindian, COSTA RICA, CYP2C19, CYP2C9, CYP2D6, Genomic ancestryAutores:Adrián LLerena, Alonso-Vilatela E., Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Ferreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Monroy-Jaramillo N., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Santiago Terán, Sarmiento A.P., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Vázquez T.C.Fuentes:scopusPredictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen
ReviewAbstract: Bevacizumab was the first molecular-targeted antiangiogenic therapy approved for the treatment of mePalabras claves:Bevacizumab, Biomarker, Cáncer, colorectalAutores:Adrián LLerena, Alonso I., Arroyo G., de Andrés F., Estévez-Carrizo F.E., González-Vacarezza N., Martínez J.Fuentes:scopusTo Genotype or Phenotype for Personalized Medicine? CYP450 Drug Metabolizing Enzyme Genotype-Phenotype Concordance and Discordance in the Ecuadorian Population
ArticleAbstract: Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing enzymes confPalabras claves:Biomarkers, developing world omics, Diagnostic Medicine, Innovation Systems, personalized medicine, Systems DiagnosticsAutores:Adrián LLerena, de Andrés F., Enrique Terán, Francisco J.López Hernández, Santiago TeránFuentes:googlescopus