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An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
ReviewAbstract: Importance of the field: The increase in life expectancy in developed countries has given rise to sePalabras claves:Alzheimer's disease, apoptosis, Neuroprotective drugs, Parkinson's DiseaseAutores:Antoni Camins, Folch J., Junyent F., Pallás M., Sureda F.X., Verdaguer E., Zárate C.B.Fuentes:scopusAntiapoptotic drugs: A therapautic strategy for the prevention of neurodegenerative diseases
ReviewAbstract: The purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegPalabras claves:Alzheimer's disease, apoptosis, Cyclin-dependent kinases, Glutamate receptors, Neuronal cell death, Neuroprotective drugs. apoptosis, Parkinson's DiseaseAutores:Antoni Camins, Auladell C., Canudas A.M., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Sureda F.X., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusGSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons
ArticleAbstract: In the present study, we evaluated the effects of roscovitine (Rosco) and flavopiridol (Flavo), bothPalabras claves:apoptosis, Cerebellar granular cells, flavopiridol, GSK3β, RoscovitineAutores:Antoni Camins, Auladell C., de la Torre A.V., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusEvaluation of hypoxia inducible factor expression in inflammatory and neurodegenerative brain models
ArticleAbstract: The neuroinflammatory process is thought to contribute to the progression of neurological disordersPalabras claves:Alzheimer's, apoptosis, APP/PS1, c-Jun, HIF-1αAutores:Antoni Camins, Auladell C., Brox S., de la Torre A.V., De Lemos M.L., Folch J., Lazarowski A., Pallás M., Petrov D., Zárate C.B.Fuentes:scopusEffects of MPP<sup>+</sup> on the molecular pathways involved in cell cycle control in B65 neuroblastoma cells
ArticleAbstract: The toxicity caused by cell exposure to 1-methyl-4-phenylpyridinium ion (MPP+) is a useful model inPalabras claves:apoptosis, Caspases, cell cycle, γH2AXAutores:Antoni Camins, Folch J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Verdaguer E., Zárate C.B.Fuentes:scopusInhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis
ReviewAbstract: Over the last few decades, understanding of the mechanisms involved in the process of neuronal'cellPalabras claves:apoptosis, Cyclin dependent kinases, E2F-1, NeuronAutores:Antoni Camins, Canudas A.M., Folch J., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusMice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus
ArticleAbstract: The Fas receptor (FasR)/Fas ligand (FasL) system plays a significant role in the process of neuronalPalabras claves:apoptosis, Caspase-3, FAS, Kainic acid, Microglia, neuroprotectionAutores:Antoni Camins, Auladell C., De Lemos M.L., Ettcheto M., Folch J., Gómez-Sintes R., Junyent F., Lucas J.J., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusRole of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration
ReviewAbstract: Chemoconvulsants that induce status epilepticus in rodents have been widely used over the past decadPalabras claves:apoptosis, C-Jun N-terminal kinase signaling pathway, hippocampus, Kainic acid, neuroprotection, ReviewAutores:Antoni Camins, Auladell C., Busquets O., De Lemos M.L., Ettcheto M., Folch J., Lazarowski A., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusProsurvival role of JAK/STAT and Akt signaling pathways in MPP <sup>+</sup>-induced apoptosis in neurons
ArticleAbstract: In the present study the role of JAK/STAT and Akt in apoptosis was evaluated in cerebellar granule cPalabras claves:Akt, apoptosis, MPP +, STAT3, Cerebellar granule cellsAutores:Alvira D., Antoni Camins, de la Torre A.V., Folch J., Junyent F., Pallás M., Sureda F.X., Verdaguer E., Yeste-Velasco M., Zárate C.B.Fuentes:scopus